You generally want air mixing, so it doesn't necessary matter where the units are. There's an entire procedure that HVAC+D contractors (should) follow when des

You generally want air mixing, so it doesn't necessary matter where the units are. There's an entire procedure that HVAC+D contractors (should) follow when designing a new system (and possibly for retrofits/renos) on just selecting the vents at the end of your ducts for this: * https://www.acca.org/standards/technical-manuals/manual-t https://www.acca.org/standards/technical-manuals/manual-t * https://www.nrel.gov/docs/fy12osti/53352.pdf https://www.nrel.gov/docs/fy12osti/53352.pdf