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You'll have to do a genetic test. Nebula, 23andme, etc. Then look at CYP1A2, see if you have the C/C genotype. Definitely read the Genetic Life Hacks article
by aantix 3y ago
You'll have to do a genetic test. Nebula, 23andme, etc.
Then look at CYP1A2, see if you have the C/C genotype.
Definitely read the Genetic Life Hacks article that I linked to above.
- grvdrm 3y agoSo if C/C then slow metabolizer?
- aantix 3y agoCorrect. C/C is the genotype. Marker rs762551, as another poster noted above. For 23andme customers: https://you.23andme.com/tools/data/?query=rs762551 https://you.23andme.com/tools/data/?query=rs762551
- throwaway128128 3y agoThank you for sharing your link. Groan, I'm A/C!!
- grvdrm 3y agoThat's great - this all came in time for me to run it by my doc today during an annual physical.
- deleted 3y ago[deleted]
- _yb2s 3y agoCYP1A2 is the whole gene- you need to look at marker rs762551 within CYP1A2. Both the C/C and A/C genotype are slow caffeine metabolizers. The most common genotype is A/A, which is a fast metabolizer. https://www.ncbi.nlm.nih.gov/snp/rs762551 https://www.ncbi.nlm.nih.gov/snp/rs762551
- jamroom 3y agoDo you have a link to one that shows A/C? I'm only seeing C/C (I'm A/C so curious). Thanks!
- _yb2s 3y agohttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014233/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014233/ This seems to be the original paper. I don't find this paper particularly meaningful, but the effects they did observe showed A/C and C/C to be about the same, and both different than A/A. This is based on a 5 hour after caffeine ingestion blood test in smokers. They found no differences in the non-smokers, but those were urine tests taken at variable times (whenever they peed), which seems sketchy to me. Based on this study, subsequent studies (e.g. https://pubmed.ncbi.nlm.nih.gov/16522833/ https://pubmed.ncbi.nlm.nih.gov/16522833/) seem to group A/C and C/C together, and not look at them independently. C/C is rare enough that studies have trouble getting many individuals from that group.
- dommer 3y agoStay away from 23andme if you have any privacy concerns. I've worked with providers of DNA insights and advice that don't build their revenue model on selling your data. For example DNAPal.me
- astrange 3y agoThey do not sell your data; Facebook and Google also don't sell your data. Your DNA is worthless[0] and impossible to hide. If someone did want your DNA there is nothing you could do to stop them. You leave it everywhere you go. [0] except to your children you don't know you have
- Obscurity4340 3y agoYeah, but why not support companies doing "the right thing" and nudge the trend towards companies that respect and preserve the privacy interests of their customers.
- astrange 3y agoThey do respect it. You have to sign up for research and fill out a thousand surveys before any of that data is used for… research.
- Obscurity4340 3y agoSo why's everyone making such a fuss about 23&me this week?
- astrange 3y agoJournalists are kind of bad at understanding how things actually work.
- Obscurity4340 3y agoI really wish there were more outlets like how for the legal/news junkie circuit we have things like MeidasTouch or whatever its called and the other YouTuber journalists (they deserve that umofficial title because what they do is top shelf journalism or at least investigative YouTubing.