Oh wow, this is a pretty gnarly issue for the Python packaging story, considering the looming deprecation of setup.py. I traced the discussion to [1], which is

Oh wow, this is a pretty gnarly issue for the Python packaging story, considering the looming deprecation of setup.py. I traced the discussion to [1], which is an interesting read, but it seems that progress on this died out in April, at least on the Python side. [1]: https://discuss.python.org/t/linux-distro-patches-to-sysconfig-are-changing-pip-install-prefix-outside-virtual-environments/18240/34 https://discuss.python.org/t/linux-distro-patches-to-sysconf...