4 ms·

I posted this because I have both an immune deficiency and a serious mood disorder and I carry the polymorphisms they talk about in this article. I was blown aw

I posted this because I have both an immune deficiency and a serious mood disorder and I carry the polymorphisms they talk about in this article. I was blown away when I found this because I knew it was true that zinc cured both of my issues for the most part. I finally got my doctors to give me a zinc test and I was deficient even though I was eating oysters, nearly daily and taking zinc supplements. So I have this transport problem with zinc and slc30a9, but also I have several genes that seem to need zinc more than other people. (PNP for one) I’ve compared my genetics with a group of 12 other peoples genetics who are friends of mine so I know how much of an oddball I am. I am bragging here, because I found this out by myself. My haplotype is a very ancient haplotype, which originates around 50,000 years ago, and this links me with the Denisovans as well.

cgh 3y ago
Did you increase your zinc supplementation further? It sounds like you have had some success with self-treatment so I’m curious what you did.
- Podgajski 3y ago
  I found it was not only the zinc, but omega-3 from seafood was even more crucial. Also, lowering my omega 6. Omega 3 three increases the transport of zinc through these zinc transporters. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145306/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145306/ When I was first found deficient , I took 200 mg of zinc sulfate which has 50 mg of elemental zinc for quite a few weeks, and there was no change. It wasn’t until I changed my fatty acid intake that my levels got up to .81. Also, I found that Zand zinc lozenges, which contain, zinc, methionine, will raise my zinc faster than a lot of tablet supplements. It may be that I get more absorption in my mouth, then in my gut. But before doing this, you should get both your zinc and copper tested. Zinc will inhibit copper absorption and can end up in a deficiency after a while. I still eat a lot of muscles since they’re very well balanced in zinc and copper.
  - datameta 3y ago
    Can second this, raising my omega-3 ratio is one of the most effective dietary changes that helped my inflammation.
    - Podgajski 3y ago
      I will add to this why omega-3 helps with inflammation in pain as well. Most people don’t realize that we make our own endogenous cannabinoids and they’re made from omega-3. No need for the weed! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145306/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145306/
      - datameta 3y ago
        I'm curious about what research you meant to link, I think this is a duplicate link perhaps
  - cgh 3y ago
    Interesting, thanks for the info. It's good that you found a simple dietary intervention that improved your life so significantly. I eat a lot of fish, mostly herring and almost every day, so I wonder if my omega 3 is high or could be higher and if so, what the effects might be.
myth_drannon 3y ago
Did you use off the shelves DNA tests or something more complex and expensive?
- Podgajski 3y ago
  I used 23 and me, both the V4 and the V5 chip to confirm. I had an order in with nebula genomics, but it fell through.
  - GordonS 3y ago
    What specifically should I look for in 23andMe to find this please? I guess I should use the raw data explorer and enter SLC30A9, but what should I expect to see if I have this issue?
    - Podgajski 3y ago
      You need to download and learn how to interpret your raw data. I’m sorry, but it’s too much information for me to convey here.
rzmmm 3y ago
Maybe I misunderstood something, but the article seems to highlight how the genetic variant of SLC30A9 is protective against lack of zinc and cold, while it predisposes to some mental health issues. So individuals with the variant are less likely to be zinc deficient.
- strbean 3y ago
  It reads to me like they don't know the specific effects on zinc requirements or deficits for a subject with this variant. Just vague statements that it "affects zinc transport" and "causes a new zinc balance within the cell". Maybe this variant increases survival rates with an otherwise zinc deficient diet, by essentially allocating more zinc to basic survival needs and less zinc to fluff like mental wellbeing?
  - Podgajski 3y ago
    It’s also possible that they were eating a lot more high zinc foods in cold climates (think organ meats and seafood like mussels). Getting too much zinc is as bad as getting too little so genetic adaptation would favor slower intestinal zinc transport and higher mitochondrial, zinc export which is what the SLC30A9 gene does. So now, those of us who carry this variant and are eating a lower zinc diet get way too deficient to easily.
  - rzmmm 3y ago
    > Maybe this variant increases survival rates with an otherwise zinc deficient diet, by essentially allocating more zinc to basic survival needs and less zinc to fluff like mental wellbeing? That's interesting idea, it sounds plausible but I'm not an expert in this area. I'd like to add that in the article paper they talk about "hard selective sweeps" for this gene variant, which implies that the variant had especially strong influence on survival. AFAIK these selective sweeps often bring on some secondary traits which are a "side product" (spandrel) of the primary trait.
yieldcrv 3y ago
I’ve been wondering if I have a transport problem for Vitamin D and how I would go about finding that out I have decent consumption and decent sun and yet wind up deficient every couple of years
- Podgajski 3y ago
  It’s probably not a transport issue, but a conversion issue. I would check out your CYP2R1 genetics. https://medlineplus.gov/genetics/gene/cyp2r1/#:~:text=The%20CYP2R1%20gene%20provides%20instructions,D3%2C%20also%20known%20as%20calcitriol https://medlineplus.gov/genetics/gene/cyp2r1/#:~:text=The%20....

cgh 3y ago

Did you increase your zinc supplementation further? It sounds like you have had some success with self-treatment so I’m curious what you did.

Podgajski 3y ago
I found it was not only the zinc, but omega-3 from seafood was even more crucial. Also, lowering my omega 6. Omega 3 three increases the transport of zinc through these zinc transporters. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145306/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145306/ When I was first found deficient , I took 200 mg of zinc sulfate which has 50 mg of elemental zinc for quite a few weeks, and there was no change. It wasn’t until I changed my fatty acid intake that my levels got up to .81. Also, I found that Zand zinc lozenges, which contain, zinc, methionine, will raise my zinc faster than a lot of tablet supplements. It may be that I get more absorption in my mouth, then in my gut. But before doing this, you should get both your zinc and copper tested. Zinc will inhibit copper absorption and can end up in a deficiency after a while. I still eat a lot of muscles since they’re very well balanced in zinc and copper.
- datameta 3y ago
  Can second this, raising my omega-3 ratio is one of the most effective dietary changes that helped my inflammation.
  - Podgajski 3y ago
    I will add to this why omega-3 helps with inflammation in pain as well. Most people don’t realize that we make our own endogenous cannabinoids and they’re made from omega-3. No need for the weed! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145306/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145306/
    - datameta 3y ago
      I'm curious about what research you meant to link, I think this is a duplicate link perhaps
- cgh 3y ago
  Interesting, thanks for the info. It's good that you found a simple dietary intervention that improved your life so significantly. I eat a lot of fish, mostly herring and almost every day, so I wonder if my omega 3 is high or could be higher and if so, what the effects might be.

myth_drannon 3y ago

Did you use off the shelves DNA tests or something more complex and expensive?

Podgajski 3y ago
I used 23 and me, both the V4 and the V5 chip to confirm. I had an order in with nebula genomics, but it fell through.
- GordonS 3y ago
  What specifically should I look for in 23andMe to find this please? I guess I should use the raw data explorer and enter SLC30A9, but what should I expect to see if I have this issue?
  - Podgajski 3y ago
    You need to download and learn how to interpret your raw data. I’m sorry, but it’s too much information for me to convey here.

rzmmm 3y ago

Maybe I misunderstood something, but the article seems to highlight how the genetic variant of SLC30A9 is protective against lack of zinc and cold, while it predisposes to some mental health issues. So individuals with the variant are less likely to be zinc deficient.

strbean 3y ago
It reads to me like they don't know the specific effects on zinc requirements or deficits for a subject with this variant. Just vague statements that it "affects zinc transport" and "causes a new zinc balance within the cell". Maybe this variant increases survival rates with an otherwise zinc deficient diet, by essentially allocating more zinc to basic survival needs and less zinc to fluff like mental wellbeing?
- Podgajski 3y ago
  It’s also possible that they were eating a lot more high zinc foods in cold climates (think organ meats and seafood like mussels). Getting too much zinc is as bad as getting too little so genetic adaptation would favor slower intestinal zinc transport and higher mitochondrial, zinc export which is what the SLC30A9 gene does. So now, those of us who carry this variant and are eating a lower zinc diet get way too deficient to easily.
- rzmmm 3y ago
  > Maybe this variant increases survival rates with an otherwise zinc deficient diet, by essentially allocating more zinc to basic survival needs and less zinc to fluff like mental wellbeing? That's interesting idea, it sounds plausible but I'm not an expert in this area. I'd like to add that in the article paper they talk about "hard selective sweeps" for this gene variant, which implies that the variant had especially strong influence on survival. AFAIK these selective sweeps often bring on some secondary traits which are a "side product" (spandrel) of the primary trait.

yieldcrv 3y ago

I’ve been wondering if I have a transport problem for Vitamin D and how I would go about finding that out I have decent consumption and decent sun and yet wind up deficient every couple of years

Podgajski 3y ago
It’s probably not a transport issue, but a conversion issue. I would check out your CYP2R1 genetics. https://medlineplus.gov/genetics/gene/cyp2r1/#:~:text=The%20CYP2R1%20gene%20provides%20instructions,D3%2C%20also%20known%20as%20calcitriol https://medlineplus.gov/genetics/gene/cyp2r1/#:~:text=The%20....