In the speedrunning community there are plenty of players who can fairly reliably perform frame-accurate inputs (i.e. press a button exactly on a specific 1/60t

In the speedrunning community there are plenty of players who can fairly reliably perform frame-accurate inputs (i.e. press a button exactly on a specific 1/60th of a second) so it seems to me that you would have a very, very hard time distinguishing the best legitimate players from cheaters.