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(warning: ignorant curiosity from someone with no chemical engineering background) This is a nice design: the chiral DNA turbine follows a leading leash into t
by w10-1 3y ago
(warning: ignorant curiosity from someone with no chemical engineering background)
This is a nice design: the chiral DNA turbine follows a leading leash into the nanopore, and the trailing cap keeps it from flowing through. The ion/electrical differential drives the turbine blades to turn (presumably the cap/leash assymmetry requires unidirectional flow).
What's unclear is how this can be converted to work in the presence of ionic flow.
It's unclear if the cap or leash could be repurposed; they're presumably spinning along with the turbine. That leaves the chiral arms, passing by the nanopore walls. I could see some charge-dependent reaction resulting from passing a charged arm-tip proximal to the nanopore-wall (enzyme), but by hypothesis we're in a charged flow so that seems like a no-go.
The converse question is whether a charged DNA arms could be induced to spin by the nanopore; that could actually drive flow (albeit likely not against any ionic or osmotic current, so it would be hard to see how it could be useful).
On the other hand, something like this might be useful not as a motor but as a discrete gating factor, e.g., to serialize flow of other molecules through a nanopore. E.g., to improve quality in the current nanopore DNA sequencing, a slow rotation time (5/s here) could enable an upstream nanopore to select one segment of DNA to be read by a downstream nanopore without the interaction of the to-be-processed segment tail with other DNA molecules near the nanopore entry. (but that might already be a solved problem for all I know.)