Puberty blockers have a long use in children. Unlike a lot of paediatric medications puberty blockers are licensed for use in children, and are used for their l

Puberty blockers have a long use in children. Unlike a lot of paediatric medications puberty blockers are licensed for use in children, and are used for their licensed use (blocking puberty), albeit for a different population (gender incongruent children with strong trans indicators, instead of children with precocious puberty). This - being licensed in children, and being used mostly in line with the license - is better than many paediatric meds. We have a lot of research about use in precocious puberty - they meds are mostly harmless. We don't have a huge amount of research in trans children, but that's for exactly the same reason we don't have research in a bunch of different meds for children.