Unless civilization is destroyed after a nuclear war, solar event, something else. Knowledge could be lost in a handful of generations. Maybe a global pandemic

Unless civilization is destroyed after a nuclear war, solar event, something else. Knowledge could be lost in a handful of generations. Maybe a global pandemic makes everyone have constant debilitating brain fog and everything just stops working. I think the right actor in the right place could make these things (except the solar thing) happen. Although a good point to consider is that we have lost the vast majority of information about the past, so it's not like the old way of writing stone tablets or whatever is necessarily good.