4 ms·
Cologuard has a significantly high false positive rate, as far as I’m aware.
by stouset 3y ago
Cologuard has a significantly high false positive rate, as far as I’m aware.
- huytersd 3y agoFalse positives are bad but not disastrous. How bad are the false negatives?
- matheusmoreira 3y agoManufacturer claims around 8% false negatives, 92%-94% sensitivity, 87%-90% specificity and 99.94% negative predictive value. Published study: https://pubmed.ncbi.nlm.nih.gov/24645800/ https://pubmed.ncbi.nlm.nih.gov/24645800/ It appears they calculated the negative predictive value based on the population sample of that study. It may differ significantly from the negative predictive value for the general population.
- matheusmoreira 3y agoAll screening tests do. In general, cancer screening employs highly sensitive tests which are supposed to react to anything that even remotely looks like cancer. Negative results are relatively trustworthy while positive results justify further testing with more specific tests which may be more risky, more expensive or both. Colonoscopy is an example of a test that is both expensive and risky.
- fsckboy 3y agodoes a cologuard false positive indicate a colonoscopy? if so, as long as the false negatives aren't substantially worse, it sounds like a win.
- bluGill 3y agoYes. If it finds anything you get called very high risk and get right in. My doctor sent me to cologuard because the people doing colonoscopies had a year long waiting list, I don't need to get in, but if the test found something they would let me skip the line and i'd be in a few weeks later. Since it didn't i'm not in line at all, but I need a new test in three years, while the colonoscopie is good for ten.