Fully agree on your 50 years ago point. The crux of the matter seems to be how grants are awarded. Alzheimers Disease research is a case in point. [0] What do

Fully agree on your 50 years ago point. The crux of the matter seems to be how grants are awarded. Alzheimers Disease research is a case in point. [0] What do do about it? There should be a "crazy ideas bin" that forces a percentage of funds for big research problems to be directed to investigations of off the wall approaches. We would find out who the good revolutionaries are and could even count them.