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PDE5 inhibitors like Viagra and Cialis have been demonstrated to improve endothelial and nerve function by improving blood supply, leading to local release of g
by Llamamoe 3y ago
PDE5 inhibitors like Viagra and Cialis have been demonstrated to improve endothelial and nerve function by improving blood supply, leading to local release of growth factors - in humans, some of the erectile function improvement is permanent, and moise models of diabetic neuropathy demonstrate lasting nerve function improvements.
They improve cerebrovascular bloodflow as well, iirc.
- AlanYx 3y agoThe odd thing is that PDE5 inhibitors have also been shown to be associated with increased risk of sensorineural hearing loss (both short term and long-term).
- Llamamoe 3y agoI believe that they have the potential to cause optic nerve compression, though severe side effects are extremely rare here. Not sure what their effect on the ear might be, but it wouldn't be the first time the same protein had wildly different effects in different parts of the body.