Right. So if the effect of the ketamine on depression relates to the conscious experience of taking it, and not simply the unconscious chemical interactions, th

Right. So if the effect of the ketamine on depression relates to the conscious experience of taking it, and not simply the unconscious chemical interactions, then isn't scheduling the dose at a time when the person is unconscious a significant factor in whether or not it's going to be more effective than placebo? We could likely replicate this format to show that mushrooms are no better than placebo for depression or that MDMA is no better for PTSD than placebo. Your assumption that "if ketamine helps with depression we should improvements vs placebo" ignores the considerable likelihood that previous effects in research are the result of conscious interactions with the drug which aren't present in this study. "It sounds like ketamine has a pronounced effect/high" - yeah, and maybe that's the meaningful effect on depression, no?