Depends on the rocket fuel. Oxygen, methane, hydrogen are basically completely non-toxic. RP-1 is a pure form of kerosene and is non-toxic enough that it doesn'

Depends on the rocket fuel. Oxygen, methane, hydrogen are basically completely non-toxic. RP-1 is a pure form of kerosene and is non-toxic enough that it doesn't need special handling. Hydrazine, fuming nitric acid, nitrogen tetroxide... basically all hypergolic propellants are absurdly toxic. The SpaceX tests at Boca Chica have been almost entirely oxygen, methane, and RP-1.