4 ms·
I can follow what you are saying because of what I learned in the book Immune by Philipp Dettmer, which I highly recommend for a popular-level introduction to t
by joshuahedlund 3y ago
I can follow what you are saying because of what I learned in the book Immune by Philipp Dettmer, which I highly recommend for a popular-level introduction to the complexities of the immune system. The whole bit about the "presentation windows" that cells use to communicate if they are infected, and how some viruses try to fight that by not presenting anything, and how the immune system tries to fight _that_ by deleting cells that don't present anything... fascinating stuff!
- pazimzadeh 3y agoThanks for the book recommendation. Another example of how almost any cell contributes to immunity is that depending on the way a cell dies (apoptosis vs pyroptosis vs necroptosis), it can release its contents, including nuclear proteins, and other "Damage-associated molecular patterns" which act as an inflammatory recruiter of other immune cells. https://en.wikipedia.org/wiki/Damage-associated_molecular_pattern https://en.wikipedia.org/wiki/Damage-associated_molecular_pa... For pyroptosis this includes endothelial cells, epithelial cells, neurons, heart muscle cells, liver cells, fibroblasts, and pancreatic β-cells. On top of this, there are several ways that "non-immune" cells are constantly doing internal immune tasks, or performing 'citizens arrests' if you will, including: restriction factors, cellular stress response, autophagy, and viral RNA/DNA detection. For example, many "non-immune" cells express Toll-like receptors which are used to detect "Pathogen-associated molecular patterns". https://en.wikipedia.org/wiki/Pathogen-associated_molecular_pattern https://en.wikipedia.org/wiki/Pathogen-associated_molecular_...
- mdswanson 3y ago+10 for Philipp Dettmer's excellent Immune book.