Beyond demographics and geography, malaria is just hard. It's not a virus with fairly stable antigenic targets - it's a parasite that readily develops resistanc

Beyond demographics and geography, malaria is just hard. It's not a virus with fairly stable antigenic targets - it's a parasite that readily develops resistance to things. This is indeed huge, even if the effect is only modest on a per-person basis, because we're still talking about a tremendous number of the world's population being protected.