4 ms·
Actually, all cause is the right metric. Let's say the vaccine stops 100% of malaria but causes severe heart attacks. You'd probably want to know that. I did
by michaelrpeskin 3y ago
Actually, all cause is the right metric. Let's say the vaccine stops 100% of malaria but causes severe heart attacks. You'd probably want to know that. I didn't review _this_ study, so I won't comment on the quality of analysis, but what you want to know about a vaccine is "effectivity" does it stop contraction and spread of the illness and "safety" does it not cause any other problems that in aggregate are worse than the illness (all cause mortality is one metric here).
- Fomite 3y agoAnd indeed there are a number of trials that show a decrease in all cause mortality (mass childhood administration of azithromycin comes to mind) that we'd miss if we were just looking at already known endpoints.