The phrasing here definitely makes you wonder how big is the group that experiences moderate side effects that are moderately unpleasant and moderately difficul

The phrasing here definitely makes you wonder how big is the group that experiences moderate side effects that are moderately unpleasant and moderately difficult to manage, and what do these qualifying terms actually mean in terms of severity and overall negative impact on a patient? A small group that has severe side effects and finds them very difficult to manage is kind of a big deal in a class of drugs that actually have small effect size in the medical literature.