4 ms·
One difference would be that you can stop any treatment in case of adverse events. But you can’t remove CAR T cells from the body once they’re in.
by f6v 3y ago
One difference would be that you can stop any treatment in case of adverse events. But you can’t remove CAR T cells from the body once they’re in.
- KaiserPro 3y agoI mean yeah, its about balancing risks. I'm guessing that a ~2% chance of a cascade would mean that its not likley to be given as a first like of defence.
- bluGill 3y agoIn a lot of cases we don't have other first line options. it may be no treatment die in 6 months, standard treatment die in 10 months, or this where 2% die in 1 month but 98% are cancer free 1 year later. All numbers above made up, but those are often what we are dealing with. Of course where we have other cancer treatments that works well those should be a first line (at least for now - who knows how this will advance), but all too often we don't have good options.
- qclibre22 3y ago> you can’t remove CAR T cells Well there working on blood purification in severe cases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245117/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245117/ "Four-day extracorporeal blood purification resulted in complete resolution of immune effector cell-associated neurotoxicity syndrome and greater than 95% reduction in interleukin-6 levels without side effects"