In this case, it's probably not that bad as with actual VLIW: if you see that e.g. your second 16-bit instruction has to be a NOP, you just use a single 32-bit

In this case, it's probably not that bad as with actual VLIW: if you see that e.g. your second 16-bit instruction has to be a NOP, you just use a single 32-bit instruction instead; similarly for 32- and 64-bit mixes.