I don't think the mice model for ACL injuries is a very good one here. The main difference between the knee anatomy of women vs men comes from the difference in

I don't think the mice model for ACL injuries is a very good one here. The main difference between the knee anatomy of women vs men comes from the difference in pelvis, which in turns comes from the fact that human babies have huge heads. All other animals have small heads relatively speaking. The average litter size for mice is 6 to 8 pups, so the difference in pelvis size between female mice and male mice is probably very small compared to the difference for humans. Moreover, humans are bipedal, so pelvis differences result in knee differences. For the quadrupedal mice, if there are any pelvis differences they would probably not result in knee differences.