5 ms·

I feel something must be missing from this model. At face value, the abstract level summary implies that tissue remodeling and repair just... doesn't occur for

I feel something must be missing from this model. At face value, the abstract level summary implies that tissue remodeling and repair just... doesn't occur for females. That seems incredibly not plausible (in humans). I'd be interested to see similar studies with different tissue donors (obviously human would be ideal... though getting a reasonable supply of healthy young-ish human ACLs is a sad thought). I can't help but wonder if choice donor (bunnys) are having an outsized influence on the results. Bunnys are famously r-selection. Maybe mommy bunnys just... get an especially raw deal in terms of tissue remodelling potential. Also, the strain they measured in their ACLs seem high?? From what I understand human ACLs have a strain at breaking of 25-30%, so their observed strains (5-10% at 2MPa, 10-20% at 4MPA and 20-40% at 8MPa) seem... off.

rjsw 3y ago
The most common repair process right now is to be your own tissue donor, a bit of hamstring tendon is used to replace the ACL.
- chpatrick 3y ago
  I'm having that done tomorrow morning followed by 4 months of video games.
darkclouds 3y ago
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belorn 3y ago
The summary does not say that healing doesn't occur for females, but rather that the variance of healing is not effected in similar ways as for males. Males adjust their healing (or to be specific, the increased expression of anabolic genes) based on the injury. Low to medium injuries resulted in increase healing, while larger force decreased healing. This adaptation to injury allows for greater healing in average, while female rabbits maintain the same relative lower rate of healing regardless of injury. Since we are talking about rabbits it is important to look at sex difference in that species. Males fight each other with only a few being able to successfully reproduce. Female rabbits do not. Males that successfully reproduce will need to repeatably heal themselves from minor to medium injuries. Thus we could explain the variance as being a natural results of that process.
- icegreentea2 3y ago
  Yes that's true (I plead the coffee still kicking in). Even in a baseline (steady) state, where anabolic and catabolic forces are in balance, a degree of continuous tissue remodelling is taking place, that will gradually tend to heal injuries (to a first approximation).
  - darkerside 3y ago
    At least in the human body, I understand it is the lack of blood flow that typically makes the ACL a difficult ligament to repair, in both sexes
draw_down 3y ago
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rjsw 3y ago

The most common repair process right now is to be your own tissue donor, a bit of hamstring tendon is used to replace the ACL.

chpatrick 3y ago
I'm having that done tomorrow morning followed by 4 months of video games.

darkclouds 3y ago

[dead]

belorn 3y ago

The summary does not say that healing doesn't occur for females, but rather that the variance of healing is not effected in similar ways as for males. Males adjust their healing (or to be specific, the increased expression of anabolic genes) based on the injury. Low to medium injuries resulted in increase healing, while larger force decreased healing. This adaptation to injury allows for greater healing in average, while female rabbits maintain the same relative lower rate of healing regardless of injury. Since we are talking about rabbits it is important to look at sex difference in that species. Males fight each other with only a few being able to successfully reproduce. Female rabbits do not. Males that successfully reproduce will need to repeatably heal themselves from minor to medium injuries. Thus we could explain the variance as being a natural results of that process.

icegreentea2 3y ago
Yes that's true (I plead the coffee still kicking in). Even in a baseline (steady) state, where anabolic and catabolic forces are in balance, a degree of continuous tissue remodelling is taking place, that will gradually tend to heal injuries (to a first approximation).
- darkerside 3y ago
  At least in the human body, I understand it is the lack of blood flow that typically makes the ACL a difficult ligament to repair, in both sexes

draw_down 3y ago

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