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While nobody should do this, the interaction risk between an SSRI and a classical psychedelic is low. The primary concerns are serotonin syndrome, which require
by icepat 3y ago
While nobody should do this, the interaction risk between an SSRI and a classical psychedelic is low. The primary concerns are serotonin syndrome, which requires a dose far outside the level that a responsible practitioner would administer. That said, this does mean that if an error is made, the consequence is far more severe (ie: miligrams as opposed to micrograms in dosing LSD).
I have heard second-hand reports of users who tapered their SSRI treatment, and on first exposure to psychedelics, had a severe negative response (to the point of re-traumatisation). So you're correct, this is exceptionally difficult to do correctly.
- stef25 3y agoYeah, which is why maybe these treatments are ok for people with relatively "mild" symptoms / disorders (like the guy in the article with "lingering ptsd"), people who aren't being aggressively treated with SSRIs. That's the sad thing about those pills I guess, it's that you stay on them or you get better.
- icepat 3y agoIn my experience with SSRI drugs, they mask the issue by blunting the emotional response itself. Much like removing a broken leg under aesthetic, rather than setting it and casting it.
- travisjungroth 3y agoAyahuasca is a classical psychedelic and the interaction risk with SSRIs is extremely high.
- icepat 3y agoAyahuasca contains monoamine oxidase inhibitors compounds too, those are the cause of the interaction. Dimethyltryptamine itself does not carry the same interaction risk. It's a mix of monoamine oxidase inhibitors and dimethyltryptamine to prevent the stomach acid decomposing active drug.
- travisjungroth 3y agoI’m just clarifying because you said it was low risk and there’s at least one case of it being high risk.
- icepat 3y agoI'm meaning the drugs themselves, rather than drug mixtures. But this is correct, and a unique case given that it is a drug mixture. You have the same problem if you ate St. Johns Wort.