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> We conducted a comprehensive systematic search of the recent literature on cognitive outcomes associated with cannabis use and cannabinoids in adults age 50 a

> We conducted a comprehensive systematic search of the recent literature on cognitive outcomes associated with cannabis use and cannabinoids in adults age 50 and older. Although there is evidence of modest negative effects on cognition in this population, larger controlled trials using validated outcome measures are greatly needed to better understand the role of cannabinoids in cognitive aging, as small sample sizes and variability in study designs limit our ability to draw definitive conclusions at this time.

InSteady 3y ago
>Although variability in the cannabis products used, outcomes assessed, and study quality limits the conclusions that can be made, modest reductions in cognitive performance were generally detected with higher doses and heavier lifetime use. >However, larger methodologically rigorous trials and longitudinal studies that assess cognition prior to the initiation of cannabis use are greatly needed to infer a causal relationship. This need is highlighted by the fact that many negative effects on cognition that were reported by studies in this review decreased after adjusting for confounding variables (e.g., differences in premorbid IQ for users and nonusers). So heavy lifetime use and high doses may case modest cognitive impairment in older adults... or it is pure correlation, and perhaps older adults seeking strong relief have other things going on prior to heavy cannabis use that also cause cognitive impairment.
- ltbarcly3 3y ago
  'Modest' just means you don't require a helper to perform every day tasks. It can be be very debilitating, but isn't 'Major' until you can't perform every day activities on your own. For further context, Trisomy 21 (Down Syndrome) is characterized as 'mild to moderate'. Modest: No interference with independence in everyday activities, although these activities may require more time and effort, accommodation, or compensatory strategies
  - InSteady 3y ago
    Greater context, which doesn't seem to line up well with your assertion here: > ...that higher doses and heavier use of cannabis are associated with modest negative effects. These findings are consistent with other systematic reviews and meta-analyses showing similar small adverse effects on cognition in younger populations. With that said, there was also evidence of modest improvements in subjective cognition on patient-reported outcome measures, particularly for medical cannabis users.
    - ltbarcly3 3y ago
      Because of a subjective improvement? I don't follow what you mean. People believe they are subjectively driving fine while hitting every mailbox due to being drunk.

InSteady 3y ago

>Although variability in the cannabis products used, outcomes assessed, and study quality limits the conclusions that can be made, modest reductions in cognitive performance were generally detected with higher doses and heavier lifetime use. >However, larger methodologically rigorous trials and longitudinal studies that assess cognition prior to the initiation of cannabis use are greatly needed to infer a causal relationship. This need is highlighted by the fact that many negative effects on cognition that were reported by studies in this review decreased after adjusting for confounding variables (e.g., differences in premorbid IQ for users and nonusers). So heavy lifetime use and high doses may case modest cognitive impairment in older adults... or it is pure correlation, and perhaps older adults seeking strong relief have other things going on prior to heavy cannabis use that also cause cognitive impairment.

ltbarcly3 3y ago
'Modest' just means you don't require a helper to perform every day tasks. It can be be very debilitating, but isn't 'Major' until you can't perform every day activities on your own. For further context, Trisomy 21 (Down Syndrome) is characterized as 'mild to moderate'. Modest: No interference with independence in everyday activities, although these activities may require more time and effort, accommodation, or compensatory strategies
- InSteady 3y ago
  Greater context, which doesn't seem to line up well with your assertion here: > ...that higher doses and heavier use of cannabis are associated with modest negative effects. These findings are consistent with other systematic reviews and meta-analyses showing similar small adverse effects on cognition in younger populations. With that said, there was also evidence of modest improvements in subjective cognition on patient-reported outcome measures, particularly for medical cannabis users.
  - ltbarcly3 3y ago
    Because of a subjective improvement? I don't follow what you mean. People believe they are subjectively driving fine while hitting every mailbox due to being drunk.