One part of either this post or the next one talks about how pharmaceutical companies are the ones making the entry criteria, and a doctor agreeing they were si

One part of either this post or the next one talks about how pharmaceutical companies are the ones making the entry criteria, and a doctor agreeing they were silly and telling the pharma that, but nothing changed.. the companies in turn have incentives to make results look good and have a known tendency to pick the healthiest possible subjects. I agree about those doctors probably being competent but incentives are twisted and no one can extrapolate perfectly from an unrepresentative sample on an unknown drug, not even doctors or the drug creators.