8 ms·

All concerns of safety notwithstanding, which is generally fucked in the industry and government, it's pretty cool that a RNAi product was developed to be liter

All concerns of safety notwithstanding, which is generally fucked in the industry and government, it's pretty cool that a RNAi product was developed to be literally sprayed on fields -- Things have probably progressed in the 15 years since I was active in lab work, but the general consensus was RNA would fall apart if you even talked too loudly, and the people regularly working with RNA all developed weird rituals and got all twitchy and paranoid (from stress, not poisoning!)

extraduder_ire 3y ago
Even if a bunch of it falls apart, just having enough survive to be effective is all you need, really.
arrosenberg 3y ago
The progression was more-or-less figuring out how to get it to not fall apart. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238147/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238147/ https://www.matinasbiopharma.com/lnc-technology/lnc-platform https://www.matinasbiopharma.com/lnc-technology/lnc-platform
walterbell 3y ago
How about inter-generational resistance? > Hansen also wonders about the pesticide’s efficacy – and the efficacy of RNAi pesticides more generally. A 2021 Scientific Reports study assessed a similar double-stranded RNA, which was being developed for a spray to combat the same potato pest. It found that within nine generations, 11,100 times the original quantity of pesticide was needed to get the same effect – an “extremely high” level of resistance, according to the study itself.