it's impossible to know where and how an assumption will be built upon common intuition in existing science. What if the estimate for an LD50 for a new drug g

it's impossible to know where and how an assumption will be built upon common intuition in existing science. What if the estimate for an LD50 for a new drug going into a trial were an order of magnitude out due to one of the underlying inputs being an order of magnitude out. The worst case scenario is that things could die off that wrong number. If nor humans, at least a lot of rats...