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> So the immune system isn't going to find it easy to mop this up The immune system is extremely good at cleaning up unencapsulated DNA and the pseudouridine i
by shadowgovt 3y ago
> So the immune system isn't going to find it easy to mop this up
The immune system is extremely good at cleaning up unencapsulated DNA and the pseudouridine is not intended to prevent that.
- nvm0n2 3y agoThe DNA isn't unencapsulated, is it? It's inside the lipid nanoparticles that are designed to enable transfection. And the pseudouridine is there specifically to disable the immune system's usual responses.