It really depends on what you mean by that. In terms of this article, the gut biome would have to be changed by that. There are definitely different things peop

It really depends on what you mean by that. In terms of this article, the gut biome would have to be changed by that. There are definitely different things people do in preparation for anal sex that could change that environment but I'm not sure how much anal sex itself actually changes that. This doesn't account for STDs that have been known to involve the nervous system for a long time already.