4 ms·
IMHO, Sinclair is making a mistake by taking spermidine directly since it will probably deplete riboflavin (B2) because the excess spermidine will be metabolize
by Podgajski 3y ago
IMHO, Sinclair is making a mistake by taking spermidine directly since it will probably deplete riboflavin (B2) because the excess spermidine will be metabolized my Spermine oxidase which uses B2 as a cofactor
https://www.uniprot.org/uniprotkb/Q9NWM0/entry https://www.uniprot.org/uniprotkb/Q9NWM0/entry
IMO, a better way is to trigger your own body to make spermidine by getting enough Arginine and taking Manganese, B6, and keeping your methylation cycle flowing.
The pathway is as follows:
Arginine -> (Arginase, uses manganese as a cofactor) -> Ornithine -> (Ornithine decarboxylase, uses B6 as a cofactor) -> putrescine -> (Spermidine synthase which needs SAMe and Pyruvate) -> Spermidine
https://www.mdpi.com/metabolites/metabolites-12-00344/article_deploy/html/images/metabolites-12-00344-g001.png https://www.mdpi.com/metabolites/metabolites-12-00344/articl...
- Namari 3y agoShouldn't the patient take more B2 in that case?
- Podgajski 3y agoIn my opinion, yes. But I still feel the better route to increasing spermidine is finding out if you are deficiency in arginine, manganese, B6 or one of the several cofactors for the methylation cycle.
- Namari 3y agoThough, will having more Arginine, Manganese and B6 automatically trigger your own body to make spermidine? Isn't there maybe a limit when the body stops producing spermidine?
- MichaelRazum 3y agoHow about chlorella powder? That is what Bryan Johnson uses.