4 ms·
I'm really sorry for what you're going through. I lost someone very close to me to cancer recently, but it was detected so very late that treatment options wer
by highwaylights 3y ago
I'm really sorry for what you're going through. I lost someone very close to me to cancer recently, but it was detected so very late that treatment options were severely limited (immunotherapy was off the table).
Personalised cancer vaccines really seem to be the most promising avenue there is at the moment, as the problem seems to always have been that unless you can kill the tumour right to the last cell whatever is left will just adapt and grow back more resilient than before. I generally scan over tumour shrinkage in these reports (even substantial shrinkage) as palliative in nature (maybe I'm naive but I've trained myself to look at it this way). Elimination of tumours (even in a subset of patients) gives me hope as it at least means something there really is effective and can be revised on later.
- ethbr1 3y agoI'd say 'differentiated' might be a better description than 'adapt', no? With targeted therapies (by whatever means), you're killing everything with that marker with high probability. Unfortunately, tumors typically being heterogenous (tumor cells don't all carry the same markers), after you've killed everything marked... you're still left with everything else. Which I believe is why most targeted therapies use simultaneous adjuvant general therapies that help with the remainder? (Family member going through BRAF targeted therapy with some adjuvant cocktail for metastatic colon cancer)