3 ms·
> Unfortunately, Moderna won't make mRNA-4157 available under compassionate use Sorry to hear. Try contacting Immunocore in Oxford, they have a TCR therapy tha
by nextos 3y ago
> Unfortunately, Moderna won't make mRNA-4157 available under compassionate use
Sorry to hear. Try contacting Immunocore in Oxford, they have a TCR therapy that targets many tumors, including squamous ones, and they are recruiting or should make it available under compassionate use. Other companies worth looking into are Adaptimmune Therapeutics, also in Oxford, and Evaxion in Copenhagen. They are all going the semi-personalized route. So will look into your tumor type, MHC class I, etc.
- skerit 3y agoTalking about clinical trials, I'm wondering: does one, as a patient, have to go hunting & searching for these clinical trials yourself, or do doctors mention these when things start to look dire? Asking for a friend that got osteosarcoma earlier this year (in her lower left leg) that has metastasized. She already had retinoblastoma as a child due to a mutation of the RB1 gene, both are probably related. I don't want to be that friend that thinks they know better than the doctors, but I'm honestly curious.
- nextos 3y agoIn my case, we did. But I know the space well, as I work in immunology. Plus, I was frustrated because our local hospital offerings were far from the state of the art. In case of a metastasis, even more so, as adverse events are less of a concern.