3 ms·

I first learned about Spermidine on David Sinclair's Lifespan podcast last year [1]; it's one of the supplements he takes daily [2]. [1]: https://www.lifespanp

I first learned about Spermidine on David Sinclair's Lifespan podcast last year [1]; it's one of the supplements he takes daily [2]. [1]: https://www.lifespanpodcast.com/nmn-nr-resveratrol-metformin-and-other-molecules-for-longevity/ https://www.lifespanpodcast.com/nmn-nr-resveratrol-metformin... [2]: https://fastlifehacks.com/david-sinclair-supplements/ https://fastlifehacks.com/david-sinclair-supplements/

Podgajski 3y ago
IMHO, Sinclair is making a mistake by taking spermidine directly since it will probably deplete riboflavin (B2) because the excess spermidine will be metabolized my Spermine oxidase which uses B2 as a cofactor https://www.uniprot.org/uniprotkb/Q9NWM0/entry https://www.uniprot.org/uniprotkb/Q9NWM0/entry IMO, a better way is to trigger your own body to make spermidine by getting enough Arginine and taking Manganese, B6, and keeping your methylation cycle flowing. The pathway is as follows: Arginine -> (Arginase, uses manganese as a cofactor) -> Ornithine -> (Ornithine decarboxylase, uses B6 as a cofactor) -> putrescine -> (Spermidine synthase which needs SAMe and Pyruvate) -> Spermidine https://www.mdpi.com/metabolites/metabolites-12-00344/article_deploy/html/images/metabolites-12-00344-g001.png https://www.mdpi.com/metabolites/metabolites-12-00344/articl...
- Namari 3y ago
  Shouldn't the patient take more B2 in that case?
  - Podgajski 3y ago
    In my opinion, yes. But I still feel the better route to increasing spermidine is finding out if you are deficiency in arginine, manganese, B6 or one of the several cofactors for the methylation cycle.
    - Namari 3y ago
      Though, will having more Arginine, Manganese and B6 automatically trigger your own body to make spermidine? Isn't there maybe a limit when the body stops producing spermidine?
- MichaelRazum 3y ago
  How about chlorella powder? That is what Bryan Johnson uses.

Podgajski 3y ago

IMHO, Sinclair is making a mistake by taking spermidine directly since it will probably deplete riboflavin (B2) because the excess spermidine will be metabolized my Spermine oxidase which uses B2 as a cofactor https://www.uniprot.org/uniprotkb/Q9NWM0/entry https://www.uniprot.org/uniprotkb/Q9NWM0/entry IMO, a better way is to trigger your own body to make spermidine by getting enough Arginine and taking Manganese, B6, and keeping your methylation cycle flowing. The pathway is as follows: Arginine -> (Arginase, uses manganese as a cofactor) -> Ornithine -> (Ornithine decarboxylase, uses B6 as a cofactor) -> putrescine -> (Spermidine synthase which needs SAMe and Pyruvate) -> Spermidine https://www.mdpi.com/metabolites/metabolites-12-00344/article_deploy/html/images/metabolites-12-00344-g001.png https://www.mdpi.com/metabolites/metabolites-12-00344/articl...

Namari 3y ago
Shouldn't the patient take more B2 in that case?
- Podgajski 3y ago
  In my opinion, yes. But I still feel the better route to increasing spermidine is finding out if you are deficiency in arginine, manganese, B6 or one of the several cofactors for the methylation cycle.
  - Namari 3y ago
    Though, will having more Arginine, Manganese and B6 automatically trigger your own body to make spermidine? Isn't there maybe a limit when the body stops producing spermidine?
MichaelRazum 3y ago
How about chlorella powder? That is what Bryan Johnson uses.