3 ms·

Before you order your Spermidine supplements: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/

by gpt5 3y ago

fbdab103 3y ago
>(3) Results: Compared with a placebo, spermidine supplementation significantly increased spermine levels in the plasma, but it did not affect spermidine or putrescine levels. No effect on salivary polyamine concentrations was observed. Which might be fine if the metabolite is actually the responsible molecule.
jychang 3y ago
Order? Considering the source of Spermidine, might be easier to get it for free from your local glory hole
- TedDoesntTalk 3y ago
  Wheat germ is another source of spermadine and you can buy it at most supermarkets. Sprinkle over cereal
  - scns 3y ago
    It contains Phytic Acid. Might be the reason humans started removing it from wheat. It gets broken down in sour dough too. https://en.wikipedia.org/wiki/Phytic_acid?wprov=sfla1 https://en.wikipedia.org/wiki/Phytic_acid?wprov=sfla1 [edit] remove doubled word
    - goda90 3y ago
      Does the spermadine also get broken down in sour dough, or is whole wheat sour dough a potential good source?
    - TedDoesntTalk 3y ago
      What’s wrong with phytic acid? I read the link you included. The only negative seems to be it might not be digestible, unless I missed something else?
      - scns 3y ago
        It irreversible binds minerals and they get excreted i.e. you can't make use of them.
      - dcassett 3y ago
        It inhibits the absorption of iron, zinc, and calcium
- ben_w 3y ago
  Given the concentration, you'd have to drink half a litre of human seminal plasma to match one 15mg supplement pill. I have no idea what the concentration of seminal plasma is in semen, but even if the latter was pure plasma that's still 135 sessions to equal one pill.
  - RobotToaster 3y ago
    It's possible that others routes of administration have better absorption than oral.
AlexanderNull 3y ago
The 15mg/d they used in that study is just the standard dietary intake (top end, europeans). Looked a number of other studies that also used just regular intake levels as "supplementation". Weird how they all stay small when the no observable adverse effects level is much higher.
BeFlatXIII 3y ago
Helpful reminder that mice lie, monkeys exaggerate, and ferrets are not people (surprisingly enough).

Before you order your Spermidine supplements: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/

by gpt5 3y ago

Before you order your Spermidine supplements: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/

fbdab103 3y ago

>(3) Results: Compared with a placebo, spermidine supplementation significantly increased spermine levels in the plasma, but it did not affect spermidine or putrescine levels. No effect on salivary polyamine concentrations was observed. Which might be fine if the metabolite is actually the responsible molecule.

jychang 3y ago

Order? Considering the source of Spermidine, might be easier to get it for free from your local glory hole

TedDoesntTalk 3y ago
Wheat germ is another source of spermadine and you can buy it at most supermarkets. Sprinkle over cereal
- scns 3y ago
  It contains Phytic Acid. Might be the reason humans started removing it from wheat. It gets broken down in sour dough too. https://en.wikipedia.org/wiki/Phytic_acid?wprov=sfla1 https://en.wikipedia.org/wiki/Phytic_acid?wprov=sfla1 [edit] remove doubled word
  - goda90 3y ago
    Does the spermadine also get broken down in sour dough, or is whole wheat sour dough a potential good source?
  - TedDoesntTalk 3y ago
    What’s wrong with phytic acid? I read the link you included. The only negative seems to be it might not be digestible, unless I missed something else?
    - scns 3y ago
      It irreversible binds minerals and they get excreted i.e. you can't make use of them.
    - dcassett 3y ago
      It inhibits the absorption of iron, zinc, and calcium
ben_w 3y ago
Given the concentration, you'd have to drink half a litre of human seminal plasma to match one 15mg supplement pill. I have no idea what the concentration of seminal plasma is in semen, but even if the latter was pure plasma that's still 135 sessions to equal one pill.
- RobotToaster 3y ago
  It's possible that others routes of administration have better absorption than oral.

AlexanderNull 3y ago

The 15mg/d they used in that study is just the standard dietary intake (top end, europeans). Looked a number of other studies that also used just regular intake levels as "supplementation". Weird how they all stay small when the no observable adverse effects level is much higher.

BeFlatXIII 3y ago

Helpful reminder that mice lie, monkeys exaggerate, and ferrets are not people (surprisingly enough).