4 ms·

The molecule is Spermidine[0] apparently. Article: https://www.nature.com/articles/s43587-023-00498-8 https://www.nature.com/articles/s43587-023-00498-8 [0]:

The molecule is Spermidine[0] apparently. Article: https://www.nature.com/articles/s43587-023-00498-8 https://www.nature.com/articles/s43587-023-00498-8 [0]: https://en.wikipedia.org/wiki/Spermidine https://en.wikipedia.org/wiki/Spermidine

caesil 3y ago
Spermidine boosts fertility? A little on the nose.
- chaps 3y ago
  No you're supposed to swallow. The pill
gpt5 3y ago
Before you order your Spermidine supplements: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/
- fbdab103 3y ago
  >(3) Results: Compared with a placebo, spermidine supplementation significantly increased spermine levels in the plasma, but it did not affect spermidine or putrescine levels. No effect on salivary polyamine concentrations was observed. Which might be fine if the metabolite is actually the responsible molecule.
- jychang 3y ago
  Order? Considering the source of Spermidine, might be easier to get it for free from your local glory hole
  - TedDoesntTalk 3y ago
    Wheat germ is another source of spermadine and you can buy it at most supermarkets. Sprinkle over cereal
    - scns 3y ago
      It contains Phytic Acid. Might be the reason humans started removing it from wheat. It gets broken down in sour dough too. https://en.wikipedia.org/wiki/Phytic_acid?wprov=sfla1 https://en.wikipedia.org/wiki/Phytic_acid?wprov=sfla1 [edit] remove doubled word
      - goda90 3y ago
        Does the spermadine also get broken down in sour dough, or is whole wheat sour dough a potential good source?
      - TedDoesntTalk 3y ago
        What’s wrong with phytic acid? I read the link you included. The only negative seems to be it might not be digestible, unless I missed something else?
        scns 3y ago
        It irreversible binds minerals and they get excreted i.e. you can't make use of them.
        dcassett 3y ago
        It inhibits the absorption of iron, zinc, and calcium
  - ben_w 3y ago
    Given the concentration, you'd have to drink half a litre of human seminal plasma to match one 15mg supplement pill. I have no idea what the concentration of seminal plasma is in semen, but even if the latter was pure plasma that's still 135 sessions to equal one pill.
    - RobotToaster 3y ago
      It's possible that others routes of administration have better absorption than oral.
- AlexanderNull 3y ago
  The 15mg/d they used in that study is just the standard dietary intake (top end, europeans). Looked a number of other studies that also used just regular intake levels as "supplementation". Weird how they all stay small when the no observable adverse effects level is much higher.
- BeFlatXIII 3y ago
  Helpful reminder that mice lie, monkeys exaggerate, and ferrets are not people (surprisingly enough).
huytersd 3y ago
I’m being serious here but can you consume your own… and see benefits? Does it make it through the digestive system?
- tetris11 3y ago
  The cult of techbro science demands that you do so immediately without reading any prior research into the topic.
- wilg 3y ago
  Regretting reading these comments suddenly
  - huytersd 3y ago
    Well I tried to keep it as implication as possible. There’s no way to make the question not sound crude unfortunately.
- ben_w 3y ago
  Even if it did, you'll get at least as much from eating about 60g of wheat germ as an unprotected sex worker would get if they had new clients every 3.5 minutes for 8 hours.
- badcppdev 3y ago
  The study talks about how, "declining egg quality in older mice can be reversed with a dietary supplement". Sooo... unless you have a very specific genetic condition you are not going to be able to self dose and replicate the study.

caesil 3y ago

Spermidine boosts fertility? A little on the nose.

chaps 3y ago
No you're supposed to swallow. The pill

gpt5 3y ago

Before you order your Spermidine supplements: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/

fbdab103 3y ago
>(3) Results: Compared with a placebo, spermidine supplementation significantly increased spermine levels in the plasma, but it did not affect spermidine or putrescine levels. No effect on salivary polyamine concentrations was observed. Which might be fine if the metabolite is actually the responsible molecule.
jychang 3y ago
Order? Considering the source of Spermidine, might be easier to get it for free from your local glory hole
- TedDoesntTalk 3y ago
  Wheat germ is another source of spermadine and you can buy it at most supermarkets. Sprinkle over cereal
  - scns 3y ago
    It contains Phytic Acid. Might be the reason humans started removing it from wheat. It gets broken down in sour dough too. https://en.wikipedia.org/wiki/Phytic_acid?wprov=sfla1 https://en.wikipedia.org/wiki/Phytic_acid?wprov=sfla1 [edit] remove doubled word
    - goda90 3y ago
      Does the spermadine also get broken down in sour dough, or is whole wheat sour dough a potential good source?
    - TedDoesntTalk 3y ago
      What’s wrong with phytic acid? I read the link you included. The only negative seems to be it might not be digestible, unless I missed something else?
      - scns 3y ago
        It irreversible binds minerals and they get excreted i.e. you can't make use of them.
      - dcassett 3y ago
        It inhibits the absorption of iron, zinc, and calcium
- ben_w 3y ago
  Given the concentration, you'd have to drink half a litre of human seminal plasma to match one 15mg supplement pill. I have no idea what the concentration of seminal plasma is in semen, but even if the latter was pure plasma that's still 135 sessions to equal one pill.
  - RobotToaster 3y ago
    It's possible that others routes of administration have better absorption than oral.
AlexanderNull 3y ago
The 15mg/d they used in that study is just the standard dietary intake (top end, europeans). Looked a number of other studies that also used just regular intake levels as "supplementation". Weird how they all stay small when the no observable adverse effects level is much higher.
BeFlatXIII 3y ago
Helpful reminder that mice lie, monkeys exaggerate, and ferrets are not people (surprisingly enough).

huytersd 3y ago

I’m being serious here but can you consume your own… and see benefits? Does it make it through the digestive system?

tetris11 3y ago
The cult of techbro science demands that you do so immediately without reading any prior research into the topic.
wilg 3y ago
Regretting reading these comments suddenly
- huytersd 3y ago
  Well I tried to keep it as implication as possible. There’s no way to make the question not sound crude unfortunately.
ben_w 3y ago
Even if it did, you'll get at least as much from eating about 60g of wheat germ as an unprotected sex worker would get if they had new clients every 3.5 minutes for 8 hours.
badcppdev 3y ago
The study talks about how, "declining egg quality in older mice can be reversed with a dietary supplement". Sooo... unless you have a very specific genetic condition you are not going to be able to self dose and replicate the study.