4 ms·

CDC on depression and mortality: wealth, smoking, exercise reduce risk of death

25 points by mtg 3y ago

stuvie 3y ago
[flagged]
lioeters 3y ago
Smoking reduces risk of death? > Not highlighted in the CDC study and unlikely to be recommended, smoking caused the most significant reduction in mortality from all causes (HR 1.65) in both the mild and moderate to severe depression groups compared to the base model (HR 1.78). This was followed closely by physical activity (HR 1.67), which is much more likely to be encouraged.
- derstander 3y ago
  I wonder if smoking serves as a proxy for social interaction. I remember seeing someone else comment on another story about not liking smoking but liking smoking culture. And along those lines, maybe the following quote from the linked open access paper re: marital status might also suggest having a community of support might be helpful? Seems plausible to me, anyway. > Participants who were female; never married or were divorced, widowed, or separated; had poverty index ratio less than 1.30; had less than 12 years of education, or had no health insurance were more likely to have self-reported depression.
  - oldbbsnickname 3y ago
    Maybe. Or nAChRs or smokers exhibit sufficient narcissistic and hedonistic tendencies as to not off themselves directly.
    - A7C3D5 3y ago
      Hey Reddit, my parents just retired and still haven't killed themselves yet, was I raised by narcissists?
  - thejazzman 3y ago
    I'm gonna go out on a limb and say it's by reducing stress - because stress takes a massive toll over time
- kraussvonespy 3y ago
  Nicotine has antidepressive effects through increasing bioavailability of serotonin. It also shines as an antipsychotic. I’m failing to find the study right off but something like 80-90% of schizophrenics are smokers. Buspar works in smoking cessation therapy as it helps balance the drop in serotonin when quitting smoking.
  - sacnoradhq 3y ago
    There's a lack of nosological classification of meaningful sub-types of depression and their specific dysfunctions. It's currently scatter-gun, medieval treatments without bothering to measure or understand the systems affected.
    - kraussvonespy 3y ago
      100% agreed. The current system of "Sorry you feel suicidal / horribly depressed. Here are some meds that are statistically unlikely to help you but you won't know whether they help or not until ~60 days after you start taking them. What if these don't work? We'll shovel you a slightly different permutation of the same meds in hopes that what didn't work the last time will work this time. By the way, it will be another 60 days before you know whether the new meds are working or not" is terribly broken. Is it any wonder that depressed and schizophrenic people smoke?
  - tnecniv 3y ago
    Doesn’t it also provide dopamine, which a depressed person might not be getting from their life activities?
    - kraussvonespy 3y ago
      You're right. It looks like there are studies that indicate that dopamine is also increased by nicotine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946180/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946180/ Edit: er, sorry, you were probably talking about Buspar, not nicotine in regards to dopamine. Buspar does increase seratonin and dopamine, both of which are tickled to varying degrees by nicotine.

25 points by mtg 3y ago

[flagged]

Smoking reduces risk of death? > Not highlighted in the CDC study and unlikely to be recommended, smoking caused the most significant reduction in mortality from all causes (HR 1.65) in both the mild and moderate to severe depression groups compared to the base model (HR 1.78). This was followed closely by physical activity (HR 1.67), which is much more likely to be encouraged.

derstander 3y ago
I wonder if smoking serves as a proxy for social interaction. I remember seeing someone else comment on another story about not liking smoking but liking smoking culture. And along those lines, maybe the following quote from the linked open access paper re: marital status might also suggest having a community of support might be helpful? Seems plausible to me, anyway. > Participants who were female; never married or were divorced, widowed, or separated; had poverty index ratio less than 1.30; had less than 12 years of education, or had no health insurance were more likely to have self-reported depression.
- oldbbsnickname 3y ago
  Maybe. Or nAChRs or smokers exhibit sufficient narcissistic and hedonistic tendencies as to not off themselves directly.
  - A7C3D5 3y ago
    Hey Reddit, my parents just retired and still haven't killed themselves yet, was I raised by narcissists?
- thejazzman 3y ago
  I'm gonna go out on a limb and say it's by reducing stress - because stress takes a massive toll over time
kraussvonespy 3y ago
Nicotine has antidepressive effects through increasing bioavailability of serotonin. It also shines as an antipsychotic. I’m failing to find the study right off but something like 80-90% of schizophrenics are smokers. Buspar works in smoking cessation therapy as it helps balance the drop in serotonin when quitting smoking.
- sacnoradhq 3y ago
  There's a lack of nosological classification of meaningful sub-types of depression and their specific dysfunctions. It's currently scatter-gun, medieval treatments without bothering to measure or understand the systems affected.
  - kraussvonespy 3y ago
    100% agreed. The current system of "Sorry you feel suicidal / horribly depressed. Here are some meds that are statistically unlikely to help you but you won't know whether they help or not until ~60 days after you start taking them. What if these don't work? We'll shovel you a slightly different permutation of the same meds in hopes that what didn't work the last time will work this time. By the way, it will be another 60 days before you know whether the new meds are working or not" is terribly broken. Is it any wonder that depressed and schizophrenic people smoke?
- tnecniv 3y ago
  Doesn’t it also provide dopamine, which a depressed person might not be getting from their life activities?
  - kraussvonespy 3y ago
    You're right. It looks like there are studies that indicate that dopamine is also increased by nicotine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946180/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946180/ Edit: er, sorry, you were probably talking about Buspar, not nicotine in regards to dopamine. Buspar does increase seratonin and dopamine, both of which are tickled to varying degrees by nicotine.