Depends on what CPU you are running, on Zen 4 it's not supported to disable the mitigations and caused bugs/crashes. I think they did fix that exact crash but I

Depends on what CPU you are running, on Zen 4 it's not supported to disable the mitigations and caused bugs/crashes. I think they did fix that exact crash but I'd still not recommend it. New CPUs from both AMD and Intel are designed to be run with at least the default mitigations on.