2 ms·

Ultrasound-activated chemotherapy advances therapeutic potential in deep tumours

1 points by westurner 3y ago

westurner 3y ago
> In addition, the prodrug’s fluorescence property enables it to act as a multi-imaging contrast agent, allowing the visualising and reconstructing of a tumour in a semi-3D fashion. This provides accurate guidance for applying FUS at a tumour site and monitoring the drug-accumulation time. [OpenWater.cc's,] NIRS Near-Infrared Spectroscopy does not require contrast FWIU? From "Great Potential – Traditional Medicine Plant Discovered To Emit Ethereal Blue Hue" https://scitechdaily.com/great-potential-traditional-medicine-plant-discovered-to-emit-ethereal-blue-hue/?s=09 https://scitechdaily.com/great-potential-traditional-medicin... : > These natural coumarins possess unique fluorescent qualities, and one of the substances holds the potential of being utilized for medical imaging in the future. > Fluorescent substances take in UV light that’s directed at them and release vibrantly colored visible light. And some glow even more brightly when they are close together, a phenomenon seen in compounds called aggregation-induced emission luminogens (AIEgens).
westurner 3y ago
"An Ultrasound-Activatable Platinum Prodrug for Sono-Sensitized Chemotherapy" (2023) https://www.science.org/doi/10.1126/sciadv.adg5964 https://www.science.org/doi/10.1126/sciadv.adg5964 : > Abstract: Despite the great success achieved by photoactivated chemotherapy, eradicating deep tumors using external sources with high tissue penetration depth remains a challenge. Here, we present cyaninplatin, a paradigm of Pt(IV) anticancer prodrug that can be activated by ultrasound in a precise and spatiotemporally controllable manner. Upon sono-activation, mitochondria-accumulated cyaninplatin exhibits strengthened mitochondrial DNA damage and cell killing efficiency, and the prodrug overcomes drug resistance as a consequence of combined effects from released Pt(II) chemotherapeutics, the depletion of intracellular reductants, and the burst of reactive oxygen species, which gives rise to a therapeutic approach, namely sono-sensitized chemotherapy (SSCT). Guided by high-resolution ultrasound, optical, and photoacoustic imaging modalities, cyaninplatin realizes the overall theranostics of tumors in vivo with superior efficacy and biosafety. This work highlights the practical utility of ultrasound to precisely activate Pt(IV) anticancer prodrugs for the eradication of deep tumor lesions and broadens the biomedical uses of Pt coordination complexes.

1 points by westurner 3y ago

> In addition, the prodrug’s fluorescence property enables it to act as a multi-imaging contrast agent, allowing the visualising and reconstructing of a tumour in a semi-3D fashion. This provides accurate guidance for applying FUS at a tumour site and monitoring the drug-accumulation time. [OpenWater.cc's,] NIRS Near-Infrared Spectroscopy does not require contrast FWIU? From "Great Potential – Traditional Medicine Plant Discovered To Emit Ethereal Blue Hue" https://scitechdaily.com/great-potential-traditional-medicine-plant-discovered-to-emit-ethereal-blue-hue/?s=09 https://scitechdaily.com/great-potential-traditional-medicin... : > These natural coumarins possess unique fluorescent qualities, and one of the substances holds the potential of being utilized for medical imaging in the future. > Fluorescent substances take in UV light that’s directed at them and release vibrantly colored visible light. And some glow even more brightly when they are close together, a phenomenon seen in compounds called aggregation-induced emission luminogens (AIEgens).

westurner 3y ago

"An Ultrasound-Activatable Platinum Prodrug for Sono-Sensitized Chemotherapy" (2023) https://www.science.org/doi/10.1126/sciadv.adg5964 https://www.science.org/doi/10.1126/sciadv.adg5964 : > Abstract: Despite the great success achieved by photoactivated chemotherapy, eradicating deep tumors using external sources with high tissue penetration depth remains a challenge. Here, we present cyaninplatin, a paradigm of Pt(IV) anticancer prodrug that can be activated by ultrasound in a precise and spatiotemporally controllable manner. Upon sono-activation, mitochondria-accumulated cyaninplatin exhibits strengthened mitochondrial DNA damage and cell killing efficiency, and the prodrug overcomes drug resistance as a consequence of combined effects from released Pt(II) chemotherapeutics, the depletion of intracellular reductants, and the burst of reactive oxygen species, which gives rise to a therapeutic approach, namely sono-sensitized chemotherapy (SSCT). Guided by high-resolution ultrasound, optical, and photoacoustic imaging modalities, cyaninplatin realizes the overall theranostics of tumors in vivo with superior efficacy and biosafety. This work highlights the practical utility of ultrasound to precisely activate Pt(IV) anticancer prodrugs for the eradication of deep tumor lesions and broadens the biomedical uses of Pt coordination complexes.