3 ms·
study: https://www.nature.com/articles/s43018-023-00649-1 https://www.nature.com/articles/s43018-023-00649-1 https://en.wikipedia.org/wiki/6-Diazo-5-oxo-L-norl
by adamredwoods 3y ago
study: https://www.nature.com/articles/s43018-023-00649-1 https://www.nature.com/articles/s43018-023-00649-1
https://en.wikipedia.org/wiki/6-Diazo-5-oxo-L-norleucine https://en.wikipedia.org/wiki/6-Diazo-5-oxo-L-norleucine
>> DON was tested as chemotherapeutic agent in different clinical studies, but was never approved. In 2019, DON was shown to kill tumor cells while reversing disease symptoms and improve overall survival in late-stage experimental glioblastoma in mice, when combined with calorie-restricted ketogenic diet.