5 ms·

Copycat nutrient leaves pancreatic tumors starving, may inform cancer treatment

121 points by wglb 3y ago

_whiteCaps_ 3y ago
My mom died of pancreatic cancer, and followed the typical timing mentioned in the article - diagnosed and passed away 5 months later. It's a terrible disease, I'm glad to see they're making progress treating it.
- voisin 3y ago
  Sorry for your loss.
antoniuschan99 3y ago
[flagged]
- adamredwoods 3y ago
  As mentioned by experts, some of these items work when exposed directly to the tumor in vitro, but when in the human body, not effective. https://www.science.org/content/blog-post/curcumin-will-waste-your-time https://www.science.org/content/blog-post/curcumin-will-wast...
- tylerekahn 3y ago
  You shouldn’t be downvoted for this. These are all examples of supplements that a complimentary medicine specialist at a cancer center could or would recommend for a patient in addition to chemo. Different studies show different efficacies but these things are recommended to patients.
  - msla 3y ago
    "Complementary medicine" is a scam. https://sciencebasedmedicine.org/so-called-alternative-medicine/ https://sciencebasedmedicine.org/so-called-alternative-medic... https://quackwatch.org/related/altwary/ https://quackwatch.org/related/altwary/
  - bruce343434 3y ago
    I suspect the reason for downvoting is that it's a chatgpt output
    - antoniuschan99 3y ago
      Yea it’s a chatgpt output, when it comes to this type of information Google search results are good for finding definitions of glutamine for example but harder to get specific lists of things
  - msla 3y ago
    "Complementary medicine" is a scam. It is a for-profit sale of things that do not work.
    - tylerekahn 3y ago
      Complementary medicine means diet, exercise, and supplement regimens. Denying that diet has an impact on health is very strange.
      - Ralfp 3y ago
        Claiming that drinking chia tea will help you shrink pancreatic tumors is quack science.
- shiroiuma 3y ago
  >Polyphenols: Various polyphenols found in fruits, vegetables, and *teas* have been examined for their potential to affect glutamine metabolism and inhibit cancer cell growth. I wonder if this is part of why Captain Picard lived to such a healthy old age.
adamredwoods 3y ago
study: https://www.nature.com/articles/s43018-023-00649-1 https://www.nature.com/articles/s43018-023-00649-1 https://en.wikipedia.org/wiki/6-Diazo-5-oxo-L-norleucine https://en.wikipedia.org/wiki/6-Diazo-5-oxo-L-norleucine >> DON was tested as chemotherapeutic agent in different clinical studies, but was never approved. In 2019, DON was shown to kill tumor cells while reversing disease symptoms and improve overall survival in late-stage experimental glioblastoma in mice, when combined with calorie-restricted ketogenic diet.
Maarten88 3y ago
A close relative was recently diagnosed with cancer and is undergoing chemotherapy. I tried to read up on cancer research and therapies and stumbled on several youtubers interviewing Thomas Seyfried [1], a researcher who thinks cancer is caused by damage to cell mitochondria that provides energy, and not by damage to cell DNA. His theory is that cancer cells get energy by fermentation instead of oxidation (burning). Taking away suitable energy sources for this process (glucose and glutamine) would make cancer cells very vulnerable and enable treatment with much lower doses of chemicals. His advise is to attack cancer foremost by fasting and then chemicals. I think he also mentions / uses the DON chemical this article touts as a way to inhibit glutamine getting to the cancer cells. This theory seems very persuasive to me. The more research articles I read, the more they seem to confirm this theory. This article is yet another one. My relative undergoing therapy was given the advise by the doctor to eat as much as possible during chemo treatment, to stay strong and feed the immune system. Which is completely counter to this research. I am not a doctor, but I worry! [1] https://youtu.be/MakS2iRkj1Q?si=IXgad6xzJIMEckfg https://youtu.be/MakS2iRkj1Q?si=IXgad6xzJIMEckfg
- voisin 3y ago
  Check out this book: “Tripping over the Truth: The Metabolic Theory of Cancer”[0] [0] https://www.goodreads.com/book/show/23496164 https://www.goodreads.com/book/show/23496164
- deleted 3y ago
  [deleted]
- tylerekahn 3y ago
  I highly recommend the book Life Over Cancer by Keith Block and reaching out to his cancer treatment center. They combine traditional chemo with complimentary medicine techniques that are in line with what you’re talking about here (low glycogenic diet, exercise, supplements). They are amazing. https://blockmd.com/ https://blockmd.com/
  - msla 3y ago
    Complementary medicine is a scam. It is selling crap for a profit. https://quackwatch.org/related/altwary/ https://quackwatch.org/related/altwary/
stevespang 3y ago
[dead]
tegmark 3y ago
[dead]

121 points by wglb 3y ago

My mom died of pancreatic cancer, and followed the typical timing mentioned in the article - diagnosed and passed away 5 months later. It's a terrible disease, I'm glad to see they're making progress treating it.

voisin 3y ago
Sorry for your loss.

antoniuschan99 3y ago

[flagged]

adamredwoods 3y ago
As mentioned by experts, some of these items work when exposed directly to the tumor in vitro, but when in the human body, not effective. https://www.science.org/content/blog-post/curcumin-will-waste-your-time https://www.science.org/content/blog-post/curcumin-will-wast...
tylerekahn 3y ago
You shouldn’t be downvoted for this. These are all examples of supplements that a complimentary medicine specialist at a cancer center could or would recommend for a patient in addition to chemo. Different studies show different efficacies but these things are recommended to patients.
- msla 3y ago
  "Complementary medicine" is a scam. https://sciencebasedmedicine.org/so-called-alternative-medicine/ https://sciencebasedmedicine.org/so-called-alternative-medic... https://quackwatch.org/related/altwary/ https://quackwatch.org/related/altwary/
- bruce343434 3y ago
  I suspect the reason for downvoting is that it's a chatgpt output
  - antoniuschan99 3y ago
    Yea it’s a chatgpt output, when it comes to this type of information Google search results are good for finding definitions of glutamine for example but harder to get specific lists of things
- msla 3y ago
  "Complementary medicine" is a scam. It is a for-profit sale of things that do not work.
  - tylerekahn 3y ago
    Complementary medicine means diet, exercise, and supplement regimens. Denying that diet has an impact on health is very strange.
    - Ralfp 3y ago
      Claiming that drinking chia tea will help you shrink pancreatic tumors is quack science.
shiroiuma 3y ago
>Polyphenols: Various polyphenols found in fruits, vegetables, and *teas* have been examined for their potential to affect glutamine metabolism and inhibit cancer cell growth. I wonder if this is part of why Captain Picard lived to such a healthy old age.

adamredwoods 3y ago

study: https://www.nature.com/articles/s43018-023-00649-1 https://www.nature.com/articles/s43018-023-00649-1 https://en.wikipedia.org/wiki/6-Diazo-5-oxo-L-norleucine https://en.wikipedia.org/wiki/6-Diazo-5-oxo-L-norleucine >> DON was tested as chemotherapeutic agent in different clinical studies, but was never approved. In 2019, DON was shown to kill tumor cells while reversing disease symptoms and improve overall survival in late-stage experimental glioblastoma in mice, when combined with calorie-restricted ketogenic diet.

Maarten88 3y ago

A close relative was recently diagnosed with cancer and is undergoing chemotherapy. I tried to read up on cancer research and therapies and stumbled on several youtubers interviewing Thomas Seyfried [1], a researcher who thinks cancer is caused by damage to cell mitochondria that provides energy, and not by damage to cell DNA. His theory is that cancer cells get energy by fermentation instead of oxidation (burning). Taking away suitable energy sources for this process (glucose and glutamine) would make cancer cells very vulnerable and enable treatment with much lower doses of chemicals. His advise is to attack cancer foremost by fasting and then chemicals. I think he also mentions / uses the DON chemical this article touts as a way to inhibit glutamine getting to the cancer cells. This theory seems very persuasive to me. The more research articles I read, the more they seem to confirm this theory. This article is yet another one. My relative undergoing therapy was given the advise by the doctor to eat as much as possible during chemo treatment, to stay strong and feed the immune system. Which is completely counter to this research. I am not a doctor, but I worry! [1] https://youtu.be/MakS2iRkj1Q?si=IXgad6xzJIMEckfg https://youtu.be/MakS2iRkj1Q?si=IXgad6xzJIMEckfg

voisin 3y ago
Check out this book: “Tripping over the Truth: The Metabolic Theory of Cancer”[0] [0] https://www.goodreads.com/book/show/23496164 https://www.goodreads.com/book/show/23496164
deleted 3y ago
[deleted]
tylerekahn 3y ago
I highly recommend the book Life Over Cancer by Keith Block and reaching out to his cancer treatment center. They combine traditional chemo with complimentary medicine techniques that are in line with what you’re talking about here (low glycogenic diet, exercise, supplements). They are amazing. https://blockmd.com/ https://blockmd.com/
- msla 3y ago
  Complementary medicine is a scam. It is selling crap for a profit. https://quackwatch.org/related/altwary/ https://quackwatch.org/related/altwary/

stevespang 3y ago

[dead]

tegmark 3y ago

[dead]