In my e-ink newspaper, I have the driver board behind a relay (because it had an annoying idle current draw even when you tell the driver chip to go to standby,

In my e-ink newspaper, I have the driver board behind a relay (because it had an annoying idle current draw even when you tell the driver chip to go to standby, and they even added an annoying power LED ...) and do just fully shut it off between refreshes. There's some projects that forego a driver ASIC entirely and drive the waveforms directly from a MCU, although I guess this large panel has a different voltage domain.