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Why some drugs are linked with increased suicidal ideation remains a major unsolved mystery. One 2009 study identified 800+ drugs spanning categories from analg
by thedailymail 3y ago
Why some drugs are linked with increased suicidal ideation remains a major unsolved mystery. One 2009 study identified 800+ drugs spanning categories from analgesics to flu treatments to anti-cancer meds that were linked to more suicidal thoughts and suicide attempts. But the mechanism(s) by which a given drug might cause a user to contemplate suicide are almost completely unknown. This, and the equally unexplained rise in placebo responses in clinical trials, should prompt more investigations into how pharmacological molecules trigger biopsychosocial effects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749439/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749439/
- vGPU 3y agoLooks like it may modulate the release of multiple neurotransmitters, so you may want to hold your horses on the placebo study. https://www.frontiersin.org/articles/10.3389/fphar.2020.01270/full https://www.frontiersin.org/articles/10.3389/fphar.2020.0127...
- FollowingTheDao 3y agoYes, most likely GLP1 is affecting the glutamate GABA balance. (GABA = Depression) https://pubmed.ncbi.nlm.nih.gov/29129776/ https://pubmed.ncbi.nlm.nih.gov/29129776/
- funnym0nk3y 3y agoGABA = depression is a crude oversimplification. Consider benzodiazepins, which cause an increase in GABA signalling as they are allosteric modulators. They cause a significant relieve in someone who is depressed.
- FollowingTheDao 3y agoBenzodiazepins do not increase GABA. They bind to the GABA receptor and open it up for GABA to enter. If you are low in GABA this will make you feel less depressed. If you are high in GABA it will make you feel more depressed.
- vGPU 3y agoI don’t think English is their native language. You’re both saying the same thing.