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The shape is more important as a container, transporting other silencing RNA or miRNA. People have developed nano cages that act as slippery shells to deliver a
by irollboozers 15y ago
The shape is more important as a container, transporting other silencing RNA or miRNA. People have developed nano cages that act as slippery shells to deliver a payload, and so far some insanely promising results in mammalian cells.
For what it's worth, I think this will be the mechanism for majority of gene based drug delivery in 10 years.
- minikomi 15y agoOh really? cool. It's been a while since I read anything about viroids. They somehow bundle miRNAs?
- irollboozers 15y agoIt's more about using DNA/RNA nanostructures. Imagine a 3d tetrahedron with toehold overhangs made entirely of one strand of DNA/RNA that unravel to deliver the payload. From what I remember, they are soluble through lipid bilayers, making them very effective for delivery. Imagine a very small 3d hotpocket that can deliver small siRNA or miRNA. Even better, you can program a signal amplification or another message into the structure itself, e.g. joining other structures to form lock-key mechanisms like legos.