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This study seems to amount to “mitochondrial DNA damage is caused by mitochondrial DNA damage”. Yes, it’s interesting that it can spread once initiated, but wha

This study seems to amount to “mitochondrial DNA damage is caused by mitochondrial DNA damage”. Yes, it’s interesting that it can spread once initiated, but what is causing the initial damage that’s setting off the chain reaction? The only clue seems to be in this sentence: >By examining both human and mouse brains, researchers discovered that the damage to mitochondria in brain cells occurs and spreads when these cells have defects in anti-viral response genes. So this is in response to a virus? That has been a theory for a very long time.

garganzol 3y ago
It also can be: toxins, hypoxia, immunity, and genetics. Any of these factors can initiate a mitochondrial dysfunction.
keep_reading 3y ago
The paper discusses TLR4 and TLR9. TLR4 is known to interact with nickel and cause mitochondrial dysfunctions. If there's a virus involved it may be the virus is triggering the spread of the damage already done by nickel? Nickel is a surprisingly good fit for my father...