4 ms·

Full text: https://www.mdpi.com/2072-6643/15/17/3772 https://www.mdpi.com/2072-6643/15/17/3772 What is interesting here is that drinking 'diet soda' actually d

Full text: https://www.mdpi.com/2072-6643/15/17/3772 https://www.mdpi.com/2072-6643/15/17/3772 What is interesting here is that drinking 'diet soda' actually decreased the odds for girls (though not reaching statistical significance) - that strikes me as an extremely odd finding. Their discussion of 'why' was not very compelling. I have a hard time thinking there's anything causative with such a disparity in sex. I also noticed that adjusting for some of the larger confounders for autism (maternal age, SES) didn't move the needle much. I would expect there to be a much larger difference between adjusted/not-adjusted OR. Maybe there's other confounders lurking or the adjustment was insufficient.

foobiekr 3y ago
Anything involving estrogens (such as plastics) will have sex-linked impacts.
- _cenw 3y ago
  Common misconception: Most estrogens (particularly phytoestrogens, but also plastics) bind to receptors so weakly, they work more like antagonists in the presence of stronger estrogens (like red meat). It'd be like trying to do anabolic steroids while your natural testosterone is very high.
  - awestroke 3y ago
    The endocrine system is complex and involves multiple pathways and feedback loops. A single compound's weak or strong binding affinity to a receptor doesn't provide a complete picture of its physiological impact.
    - _cenw 3y ago
      This was not meant to be an exhaustive explainer, rather a single caveat to stop the "all you need is high absolute T and low absolute E" simplification in its tracks. Receptor saturation (in this case, E1 vs E2; first pass metabolism turns E2 into E1) is something I had to learn out of neccessity because my endocrinologist didn't really do anything beyond loosely following ancient standards of practice (we don't have specialized gender clinics in Germany).
yieldcrv 3y ago
girls are already underdiagnosed for autism, and cultural norms allow their neurodivergence to blend in, so the data will always be bad if the parent doesn't have a daughter diagnosed with autism
deleted 3y ago
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foobiekr 3y ago

Anything involving estrogens (such as plastics) will have sex-linked impacts.

_cenw 3y ago
Common misconception: Most estrogens (particularly phytoestrogens, but also plastics) bind to receptors so weakly, they work more like antagonists in the presence of stronger estrogens (like red meat). It'd be like trying to do anabolic steroids while your natural testosterone is very high.
- awestroke 3y ago
  The endocrine system is complex and involves multiple pathways and feedback loops. A single compound's weak or strong binding affinity to a receptor doesn't provide a complete picture of its physiological impact.
  - _cenw 3y ago
    This was not meant to be an exhaustive explainer, rather a single caveat to stop the "all you need is high absolute T and low absolute E" simplification in its tracks. Receptor saturation (in this case, E1 vs E2; first pass metabolism turns E2 into E1) is something I had to learn out of neccessity because my endocrinologist didn't really do anything beyond loosely following ancient standards of practice (we don't have specialized gender clinics in Germany).

yieldcrv 3y ago

girls are already underdiagnosed for autism, and cultural norms allow their neurodivergence to blend in, so the data will always be bad if the parent doesn't have a daughter diagnosed with autism

deleted 3y ago

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