3 ms·

> In both pivotal studies, a statistically significantly greater percentage of subjects experienced their study eyes returning to normal at all time points meas

by amluto 3y ago

> In both pivotal studies, a statistically significantly greater percentage of subjects experienced their study eyes returning to normal at all time points measured from 60 minutes through 24 hours in the Ryzumvi group compared with placebo. Thanks, FDA, industry standards, and general statistics education. This means almost nothing. How much does it help? What fraction of people are helped? Can one still see comfortably in dim light after administration of dilating drops followed by this? Does it also reverse cycloplegia?

icegreentea2 3y ago
Here's the study results: https://clinicaltrials.gov/study/NCT05134974?tab=results https://clinicaltrials.gov/study/NCT05134974?tab=results They mostly only studied pupil diameter - there is one visual acuity test measurement (at normal lighting conditions) performed at 6 hours that maybe shows improvement.
- amluto 3y ago
  So the effect on dilation is pretty large. Why doesn’t the headline say that? The accommodation results are indeed unimpressive.
  - jachee 3y ago
    Because the target audience of the headline isn’t patients, but investors.
    - amluto 3y ago
      Sure, but investors like a “significant improvement” because the FDA likes it, and IMO that is the problem.