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A NICER approach to genome editing with less mutations than CRISPR (2023)
- westurner 3y ago"AI combined with CRISPR precisely controls gene expression" (2023) https://phys.org/news/2023-06-ai-combined-crispr-precisely-gene.html https://phys.org/news/2023-06-ai-combined-crispr-precisely-g... : > Sanjana's lab teamed up with the lab of machine learning expert David Knowles to engineer a deep learning model they named TIGER (Targeted Inhibition of Gene Expression via guide RNA design) that was trained on the data from the CRISPR screens. Comparing the predictions generated by the deep learning model and laboratory tests in human cells, TIGER was able to predict both on-target and off-target activity, outperforming previous models developed for Cas13 on-target guide design and providing the first tool for predicting off-target activity of RNA-targeting CRISPRs. Would TIGER also work with NICER?
- mdwalters 3y agoYou don't need the year tag when the article is recent.
- westurner 3y agoYears later it's helpful to have the year with the title for ScholarlyArticle citations. Should be easy enough to determine that that year is this year this year.