I don't know the mechanics, my guess is they translate the MIDI notes to the scale given to them by a tuning file Here's a pretty comprehensive-looking list of

I don't know the mechanics, my guess is they translate the MIDI notes to the scale given to them by a tuning file Here's a pretty comprehensive-looking list of software instruments supporting microtuning: https://en.xen.wiki/w/List_of_microtonal_software_plugins https://en.xen.wiki/w/List_of_microtonal_software_plugins