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>In mice, they all have the same genetics, but as humans we vary more than you think. This is deliberate, so that the research question can be isolated from va

>In mice, they all have the same genetics, but as humans we vary more than you think. This is deliberate, so that the research question can be isolated from variation in mouse genetics as much as possible. Different types of research use different mouse lineages according to their purposes. Do you think scientists are not aware of the role of genetics, or the great variability? The goal is to elucidate fundamental aspects of cell function: >We conclude that metabolic maturation shapes the epigenetic landscape of cardiomyocytes No one is trying to make you take a pill or alter your lifestyle because of this research.

mikewarot 3y ago
>This is deliberate, so that the research question can be isolated from variation in mouse genetics as much as possible. The breeding process for said mice may represent an evolutionary pressure[1] that alters them sufficiently that they are no longer suitable for an analog to humans[2], unlike their wild brethren. Or so sayeth the evolutionary biologists. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC113886/#:~:text=Established%20inbred%20mouse%20strains%20have,11%2C14%E2%80%9316 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC113886/#:~:text...). [2] https://pubmed.ncbi.nlm.nih.gov/34008434/ https://pubmed.ncbi.nlm.nih.gov/34008434/