4 ms·
It probably matters immensely which specific molecule is blocked and if you block one too early in some process then critical intermediates can’t be made. Sort
by bionhoward 3y ago
It probably matters immensely which specific molecule is blocked and if you block one too early in some process then critical intermediates can’t be made. Sort of like deleting some code, it matters what’s downstream, so maybe earlier parts of this process are bad to block, but if you have a heart attack, then blocking later parts of the same process could trick your heart cells back into regenerating instead of being stable.
Also worth noting, this could be an example of hormesis. A metabolic approach to de-differentiate heart cells into a more primitive form by disrupting the way they process fats could be considered a toxic insult which triggers some defense (stemness) which is the proximate cause / helpful thing (not the toxic insult)