Agreed on the common sense stuff but disagree about the difficulty to translate this to practice. Depends if you need it from Big Pharma or if you’re biohacking

Agreed on the common sense stuff but disagree about the difficulty to translate this to practice. Depends if you need it from Big Pharma or if you’re biohacking. The authors highlight a multi step pathway and one of the steps is accumulation of alpha-ketoglutarate which is a common ketone we all already have tons of, and it increases from fasting. Seems like their research indicates there’s a second system hiding behind the first and it only turns on when you have ketones and can’t burn fat. That’s like the logical converse or contrapositive or something to fasted state. This is analogous to diabetic ketoacidosis but seems to have a healthy impact, which is surprising. TLDR: if you think about it, fatty acid oxidation pathways are some of the easiest to target (even with zero drugs…just stop eating for a few days)